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KMID : 0894520100140020083
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Development & Reproduction
2010 Volume.14 No. 2 p.83 ~ p.89
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Mutual Activities of IEX-1 and MCL-1 on the Apoptosis of Ovarian Cancer Cells
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Yoon Seong-Min
Na Soon-Young
Kim Hong-Man
Lee Kang-Seok
Bae Jee-Hyeon
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Abstract
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Apoptosis is a crucial mechanism for the proper regulation of homeostasis. BCL-2 family proteins are key molecules which control cellular survival and apoptosis. MCL-1 (myeloid cell leukemia-1) is a pro-survival member of BCL-2 family that promotes the survival of cells, and is highly expressed in diverse cancers including ovarian cancer, leukemia, and cervical cancer. Previously we identified IEX-1 (immediate early response gene X-1) as a binding partner of MCL-1. In the present study, we demonstrated that overexpression of IEX-1 induced apoptosis of ovarian cancer cells. Moreover, IEX-1 significantly attenuated the pro-survival function of MCL-1 in these cells. Also, IEX-1-induced cell death activity was able to be modulated by changes in the expression level of MCL-1. Thus, these results suggest that both IEX-1 and MCL-1 modulate each other’s function controlling cellular survival and death and the inhibitory activity of IEX-1 toward MCL-1 may be applied for the development of chemotherapeutics.
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KEYWORD
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Apoptosis, MCL-1, IEX-1, BCL-2 family, Ovarian cancer cell
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